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Regulation of p53 Stability and Apoptosis by a ROR Agonist
Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3324542/ https://ncbi.nlm.nih.gov/pubmed/22509368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034921 |
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