Mitochondrial pathway of apoptosis is ancestral in metazoans

The mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in vertebrates. In this pathway, proapoptotic members of the Bcl-2 family cause mitochondrial outer membrane permeabilization (MOMP), allowing the release of cytochrome c, which interacts with Apaf-1 to trigger...

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Detalhes bibliográficos
Main Authors: Bender, Cheryl E., Fitzgerald, Patrick, Tait, Stephen W. G., Llambi, Fabien, McStay, Gavin P., Tupper, Douglas O., Pellettieri, Jason, Alvarado, Alejandro Sánchez, Salvesen, Guy S., Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324028/
https://ncbi.nlm.nih.gov/pubmed/22416118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120680109
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