Mitochondrial pathway of apoptosis is ancestral in metazoans

The mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in vertebrates. In this pathway, proapoptotic members of the Bcl-2 family cause mitochondrial outer membrane permeabilization (MOMP), allowing the release of cytochrome c, which interacts with Apaf-1 to trigger...

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Hlavní autoři: Bender, Cheryl E., Fitzgerald, Patrick, Tait, Stephen W. G., Llambi, Fabien, McStay, Gavin P., Tupper, Douglas O., Pellettieri, Jason, Alvarado, Alejandro Sánchez, Salvesen, Guy S., Green, Douglas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324028/
https://ncbi.nlm.nih.gov/pubmed/22416118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120680109
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