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Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

The crystal structures of the ligand-binding domain (LBD) of the vitamin D receptor complexed to 1α,25(OH)(2)D(3) and the 20-epi analogs, MC1288 and KH1060, show that the protein conformation is identical, conferring a general character to the observation first made for retinoic acid receptor (RAR)...

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Autors principals: Tocchini-Valentini, G., Rochel, N., Wurtz, J. M., Mitschler, A., Moras, D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC33240/
https://ncbi.nlm.nih.gov/pubmed/11344298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091018698
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