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Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners

O-linked β-N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification found on hundreds of nuclear and cytoplasmic proteins in higher eukaryotes. Despite its ubiquity and essentiality in mammals, functional roles for the O-GlcNAc modification remain poorly defined. Here we develop...

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Detalhes bibliográficos
Main Authors: Yu, Seok-Ho, Boyce, Michael, Wands, Amberlyn M., Bond, Michelle R., Bertozzi, Carolyn R., Kohler, Jennifer J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323966/
https://ncbi.nlm.nih.gov/pubmed/22411826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114356109
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