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Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma

Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origin when a codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In the...

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Autors principals: Xu, Xia, Rock, Jason R., Lu, Yun, Futtner, Christopher, Schwab, Brian, Guinney, Justin, Hogan, Brigid L. M., Onaitis, Mark W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323959/
https://ncbi.nlm.nih.gov/pubmed/22411819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112499109
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