The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the ‘oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity t...

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Detalhes bibliográficos
Main Authors: Masson, Norma, Singleton, Rachelle S, Sekirnik, Rok, Trudgian, David C, Ambrose, Lucy J, Miranda, Melroy X, Tian, Ya-Min, Kessler, Benedikt M, Schofield, Christopher J, Ratcliffe, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323130/
https://ncbi.nlm.nih.gov/pubmed/22310300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.9
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