The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the ‘oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity t...

詳細記述

保存先:
書誌詳細
主要な著者: Masson, Norma, Singleton, Rachelle S, Sekirnik, Rok, Trudgian, David C, Ambrose, Lucy J, Miranda, Melroy X, Tian, Ya-Min, Kessler, Benedikt M, Schofield, Christopher J, Ratcliffe, Peter J
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
Scientific Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323130/
https://ncbi.nlm.nih.gov/pubmed/22310300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.9
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