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Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis()

Human frataxin (FXN) has been intensively studied since the discovery that the FXN gene is associated with the neurodegenerative disease Friedreich’s ataxia. Human FXN is a component of the NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex and activates the cysteine desulfurase and Fe-S cluster...

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書誌詳細
主要な著者: Bridwell-Rabb, Jennifer, Iannuzzi, Clara, Pastore, Annalisa, Barondeau, David P.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323110/
https://ncbi.nlm.nih.gov/pubmed/22352884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201628j
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