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Acidic residues of yeast frataxin have an essential role in Fe–S cluster assembly
Friedreich ataxia is caused by decreased levels of frataxin, a mitochondrial acidic protein that is assumed to act as chaperone in the assembly of Fe–S clusters on the scaffold Isu protein. Frataxin has the in vitro capacity to form iron-loaded multimers, which also suggests an iron storage function...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1796776/ https://ncbi.nlm.nih.gov/pubmed/17186026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400881 |
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