Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X(L) and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. While ABT-737 and its orally active analog ABT-263 ar...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Doi, Kenichiro, Li, Rongshi, Sung, Shen-Shu, Wu, Hongwei, Liu, Yan, Manieri, Wanda, Krishnegowda, Gowdahalli, Awwad, Andy, Dewey, Alden, Liu, Xin, Amin, Shantu, Cheng, Chunwei, Qin, Yong, Schonbrunn, Ernst, Daughdrill, Gary, Loughran, Thomas P., Sebti, Said, Wang, Hong-Gang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323047/
https://ncbi.nlm.nih.gov/pubmed/22311987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334532
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia