Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim

A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed th...

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Bibliographic Details
Main Authors: Cheng, Chunwei, Liu, Yan, Balasis, Maria E., Garner, Thomas P., Li, Jerry, Simmons, Nicholas L., Berndt, Norbert, Song, Hao, Pan, Lili, Qin, Yong, Nicolaou, K. C., Gavathiotis, Evripidis, Sebti, Said M., Li, Rongshi
Format: Artigo
Language:Inglês
Published: MDPI 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145318/
https://ncbi.nlm.nih.gov/pubmed/25076060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12084311
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