Hypermethylated in Cancer 1 (HIC1) Recruits Polycomb Repressive Complex 2 (PRC2) to a Subset of Its Target Genes through Interaction with Human Polycomb-like (hPCL) Proteins

HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene epigenetically silenced or deleted in many human cancers. HIC1 is involved in regulatory loops modulating p53- and E2F1-dependent cell survival, growth control, and stress responses. HIC1 is also essential for normal development because H...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Boulay, Gaylor, Dubuissez, Marion, Van Rechem, Capucine, Forget, Antoine, Helin, Kristian, Ayrault, Olivier, Leprince, Dominique
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Gene Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323039/
https://ncbi.nlm.nih.gov/pubmed/22315224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320234
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