The Receptor Tyrosine Kinase EphA2 Is a Direct Target Gene of Hypermethylated in Cancer 1 (HIC1)

The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a transcriptional repressor, is epigenetically silenced in many human tumors. Here, we show that ectopic expression of HIC1 in the highly malignant MDA-MB-231 breast cancer cell line severely impairs cell proliferation, migr...

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Detalhes bibliográficos
Main Authors: Foveau, Bénédicte, Boulay, Gaylor, Pinte, Sébastien, Van Rechem, Capucine, Rood, Brian R., Leprince, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285316/
https://ncbi.nlm.nih.gov/pubmed/22184117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329466
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