Loss of Hypermethylated in Cancer 1 (HIC1) in Breast Cancer Cells Contributes to Stress-induced Migration and Invasion through β-2 Adrenergic Receptor (ADRB2) Misregulation

The transcriptional repressor HIC1 (Hypermethylated in Cancer 1) is a tumor suppressor gene inactivated in many human cancers including breast carcinomas. In this study, we show that HIC1 is a direct transcriptional repressor of β-2 adrenergic receptor (ADRB2). Through promoter luciferase activity,...

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Main Authors: Boulay, Gaylor, Malaquin, Nicolas, Loison, Ingrid, Foveau, Bénédicte, Van Rechem, Capucine, Rood, Brian R., Pourtier, Albin, Leprince, Dominique
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285317/
https://ncbi.nlm.nih.gov/pubmed/22194601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304287
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