Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

The therapeutic benefit of the small heat shock protein αB-crystallin (HspB5) in animal models of multiple sclerosis and ischemia is proposed to arise from its increased capacity to bind proinflammatory proteins at the elevated temperatures within inflammatory foci. By mass spectral analysis, a comm...

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Detalhes bibliográficos
Main Authors: Rothbard, Jonathan B., Kurnellas, Michael P., Brownell, Sara, Adams, Chris M., Su, Leon, Axtell, Robert C., Chen, Rong, Fathman, C. Garrison, Robinson, William H., Steinman, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322989/
https://ncbi.nlm.nih.gov/pubmed/22308023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337691
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