Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21

p21(Waf1/Cip1/Sdi1) is a cyclin-dependent kinase inhibitor that mediates cell cycle arrest. Prolonged p21 up-regulation induces a senescent phenotype in normal and cancer cells, accompanied by an increase in intracellular reactive oxygen species (ROS). However, it has been shown recently that p21 ex...

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Detalhes bibliográficos
Main Authors: Masgras, Ionica, Carrera, Samantha, de Verdier, Petra J., Brennan, Paul, Majid, Aneela, Makhtar, Wan, Tulchinsky, Eugene, Jones, George D. D., Roninson, Igor B., Macip, Salvador
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322987/
https://ncbi.nlm.nih.gov/pubmed/22311974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250357
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