Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

The receptor-tyrosine kinase ErbB4 was identified as a direct regulator of hypoxia-inducible factor-1α (HIF-1α) signaling. Cleaved intracellular domain of ErbB4 directly interacted with HIF-1α in the nucleus, and stabilized HIF-1α protein in both normoxic and hypoxic conditions by blocking its prote...

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Main Authors: Paatero, Ilkka, Jokilammi, Anne, Heikkinen, Pekka T., Iljin, Kristiina, Kallioniemi, Olli-Pekka, Jones, Frank E., Jaakkola, Panu M., Elenius, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322979/
https://ncbi.nlm.nih.gov/pubmed/22308027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.299537
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