Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding

Matrix metalloproteinases release intact syndecan-1 ectodomains from the cell surface giving rise to a soluble, shed form of the proteoglycan. Although it is known that shed syndecan-1 controls diverse pathophysiological responses in cancer, wound healing, inflammation, infection, and immunity, the...

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Main Authors: Ramani, Vishnu C., Pruett, Pamela S., Thompson, Camilla A., DeLucas, Lawrence D., Sanderson, Ralph D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Glycobiology and Extracellular Matrices
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322978/
https://ncbi.nlm.nih.gov/pubmed/22298773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.330803
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