Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

An intensive recent effort to develop ATP-competitive mTOR inhibitors has resulted in several potent and selective molecules such as Torin1, PP242, KU63794, and WYE354. These inhibitors are being widely used as pharmacological probes of mTOR-dependent biology. To determine the potency and specificit...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Qingsong, Kirubakaran, Sivapriya, Hur, Wooyoung, Niepel, Mario, Westover, Kenneth, Thoreen, Carson C., Wang, Jinhua, Ni, Jing, Patricelli, Matthew P., Vogel, Kurt, Riddle, Steve, Waller, David L., Traynor, Ryan, Sanda, Takaomi, Zhao, Zheng, Kang, Seong A., Zhao, Jean, Look, A. Thomas, Sorger, Peter K., Sabatini, David M., Gray, Nathanael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322972/
https://ncbi.nlm.nih.gov/pubmed/22223645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304485
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