Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)

Hyperphosphorylated tau is the major component of neurofibrillary tangles in Alzheimer disease (AD), and the tangle distribution largely overlaps with zinc-containing glutamatergic neurons, suggesting that zinc released in synaptic terminals may play a role in tau phosphorylation. To explore this po...

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Detalhes bibliográficos
Main Authors: Sun, Xu-Ying, Wei, Yu-Ping, Xiong, Yan, Wang, Xiao-Chuan, Xie, Ao-Ji, Wang, Xiu-Lian, Yang, Yang, Wang, Qun, Lu, You-Ming, Liu, Rong, Wang, Jian-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322889/
https://ncbi.nlm.nih.gov/pubmed/22334661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309070
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