Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

The insulin receptor isoform A (IR-A) binds both insulin and insulin-like growth factor (IGF)-II, although the affinity for IGF-II is 3–10-fold lower than insulin depending on a cell and tissue context. Notably, in mouse embryonic fibroblasts lacking the IGF-IR and expressing solely the IR-A (R−/IR-...

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Main Authors: Morcavallo, Alaide, Genua, Marco, Palummo, Angela, Kletvikova, Emilia, Jiracek, Jiri, Brzozowski, Andrzej M., Iozzo, Renato V., Belfiore, Antonino, Morrione, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322853/
https://ncbi.nlm.nih.gov/pubmed/22318726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252478
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