Ligand-Mediated Endocytosis and Trafficking of the Insulin-Like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function

The insulin-like growth factor system and its two major receptors, the IGF receptor I (IGF-IR) and IR, plays a central role in a variety of physiological cellular processes including growth, differentiation, motility, and glucose homeostasis. The IGF-IR is also essential for tumorigenesis through it...

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Опубликовано в: :Front Endocrinol (Lausanne)
Главные авторы: Morcavallo, Alaide, Stefanello, Manuela, Iozzo, Renato V., Belfiore, Antonino, Morrione, Andrea
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2014
Предметы:
Endocrinology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269189/
https://ncbi.nlm.nih.gov/pubmed/25566192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00220
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