Research Resource: New and Diverse Substrates for the Insulin Receptor Isoform A Revealed by Quantitative Proteomics After Stimulation With IGF-II or Insulin

The isoform A of the insulin receptor (IR) (IR-A) is a bifunctional receptor, because it binds both insulin and IGF-II. IR-A activation by IGF-II plays a role in development, but its physiological role in adults is unknown. IGF-II signaling through IR-A is deregulated in cancer and favors tumor prog...

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Bibliografske podrobnosti
izdano v:Mol Endocrinol
Main Authors: Morcavallo, Alaide, Gaspari, Marco, Pandini, Giuseppe, Palummo, Angela, Cuda, Giovanni, Larsen, Martin R., Vigneri, Riccardo, Belfiore, Antonino
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2011
Teme:
Research Resource
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417236/
https://ncbi.nlm.nih.gov/pubmed/21680660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0484
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