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Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound
Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor, prinomastat, to 2.85 Å resolution by x-ray crystallography. Prinomastat binding is well defined by e...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322812/ https://ncbi.nlm.nih.gov/pubmed/22308038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307918 |
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