Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4(Cdt2)

The E3 ubiquitin ligase Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for destruction in S phase and after DNA damage, including Cdt1, p21, and Set8. CRL4(Cdt2) substrates contain a “PIP degron,” which consists of a canonical p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Havens, Courtney G., Shobnam, Nadia, Guarino, Estrella, Centore, Richard C., Zou, Lee, Kearsey, Stephen E., Walter, Johannes C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Protein Synthesis and Degradation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322809/
https://ncbi.nlm.nih.gov/pubmed/22303007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337683
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