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Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics

[Image: see text] We present a flexible, modular route to GlcNAc-MurNAc-oligosaccharides that can be readily converted into peptidoglycan (PG) fragments to serve as reagents for the study of bacterial enzymes that are targets for antibiotics. Demonstrating the utility of these synthetic PG substrate...

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Bibliografski detalji
Glavni autori: Gampe, Christian M., Tsukamoto, Hirokazu, Wang, Tsung-Shing Andrew, Walker, Suzanne, Kahne, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322638/
https://ncbi.nlm.nih.gov/pubmed/22505780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.09.114
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