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Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics

[Image: see text] We present a flexible, modular route to GlcNAc-MurNAc-oligosaccharides that can be readily converted into peptidoglycan (PG) fragments to serve as reagents for the study of bacterial enzymes that are targets for antibiotics. Demonstrating the utility of these synthetic PG substrate...

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Autores principales: Gampe, Christian M., Tsukamoto, Hirokazu, Wang, Tsung-Shing Andrew, Walker, Suzanne, Kahne, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322638/
https://ncbi.nlm.nih.gov/pubmed/22505780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.09.114
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