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Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics

[Image: see text] We present a flexible, modular route to GlcNAc-MurNAc-oligosaccharides that can be readily converted into peptidoglycan (PG) fragments to serve as reagents for the study of bacterial enzymes that are targets for antibiotics. Demonstrating the utility of these synthetic PG substrate...

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Detalhes bibliográficos
Main Authors: Gampe, Christian M., Tsukamoto, Hirokazu, Wang, Tsung-Shing Andrew, Walker, Suzanne, Kahne, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322638/
https://ncbi.nlm.nih.gov/pubmed/22505780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.09.114
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