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Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design

Peptidoglycan glycosyltransferases (PGTs), enzymes that catalyze the formation of the glycan chains of the bacterial cell wall, have tremendous potential as antibiotic targets. The moenomycins, a potent family of natural product antibiotics, are the only known active site inhibitors of the PGTs and...

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Bibliografske podrobnosti
Main Authors: Yuan, Yanqiu, Fuse, Shinichiro, Ostash, Bohdan, Sliz, Piotr, Kahne, Daniel, Walker, Suzanne
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493539/
https://ncbi.nlm.nih.gov/pubmed/18642800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800078a
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