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NANOMOLAR CFTR INHIBITION BY PORE-OCCLUDING DIVALENT POLYETHYLENE GLYCOL-MALONIC ACID HYDRAZIDES
Inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have potential application as antisecretory therapy in cholera. We synthesized mono- and divalent CFTR inhibitors consisting of a malonic acid hydrazide (MalH) coupled via a disulfonic stilbene linker to po...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322358/ https://ncbi.nlm.nih.gov/pubmed/18635008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.015 |
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