NANOMOLAR CFTR INHIBITION BY PORE-OCCLUDING DIVALENT POLYETHYLENE GLYCOL-MALONIC ACID HYDRAZIDES

Inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have potential application as antisecretory therapy in cholera. We synthesized mono- and divalent CFTR inhibitors consisting of a malonic acid hydrazide (MalH) coupled via a disulfonic stilbene linker to po...

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Detalhes bibliográficos
Main Authors: Sonawane, N.D., Zhao, Dan, Zegarra-Moran, Olga, Galietta, Luis J.V., Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322358/
https://ncbi.nlm.nih.gov/pubmed/18635008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.015
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