NANOMOLAR CFTR INHIBITION BY PORE-OCCLUDING DIVALENT POLYETHYLENE GLYCOL-MALONIC ACID HYDRAZIDES

Inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have potential application as antisecretory therapy in cholera. We synthesized mono- and divalent CFTR inhibitors consisting of a malonic acid hydrazide (MalH) coupled via a disulfonic stilbene linker to po...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sonawane, N.D., Zhao, Dan, Zegarra-Moran, Olga, Galietta, Luis J.V., Verkman, A.S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322358/
https://ncbi.nlm.nih.gov/pubmed/18635008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.015
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky