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Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

Neurotransmitter sodium symporters (NSSs) catalyze the uptake of neurotransmitters into cells, terminating neurotransmission at chemical synapses. Consistent with the role of NSSs in the central nervous system, they are implicated in multiple diseases and disorders. LeuT from Aquifex aeolicus, is a...

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Detalhes bibliográficos
Main Authors: Wang, Hui, Elferich, Johannes, Gouaux, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322350/
https://ncbi.nlm.nih.gov/pubmed/22245965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2215
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