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Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue
LeuT serves as the model protein for understanding the relationships between structure, mechanism and pharmacology in neurotransmitter sodium symporters (NSSs). At the present time, however, there is a vigorous debate over whether there is a single high-affinity substrate site (S1) located at the or...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432802/ https://ncbi.nlm.nih.gov/pubmed/22836580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.110 |
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