Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs

Genome-wide association studies (GWASs) are critically dependent on detailed knowledge of the pattern of linkage disequilibrium (LD) in the human genome. GWASs generate lists of variants, usually SNPs, ranked according to the significance of their association to a trait. Downstream analyses generall...

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Main Authors: Christoforou, Andrea, Dondrup, Michael, Mattingsdal, Morten, Mattheisen, Manuel, Giddaluru, Sudheer, Nöthen, Markus M., Rietschel, Marcella, Cichon, Sven, Djurovic, Srdjan, Andreassen, Ole A., Jonassen, Inge, Steen, Vidar M., Puntervoll, Pål, Le Hellard, Stéphanie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2012
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322240/
https://ncbi.nlm.nih.gov/pubmed/22444669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.02.025
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