Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs

Genome-wide association studies (GWASs) are critically dependent on detailed knowledge of the pattern of linkage disequilibrium (LD) in the human genome. GWASs generate lists of variants, usually SNPs, ranked according to the significance of their association to a trait. Downstream analyses generall...

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Autors principals: Christoforou, Andrea, Dondrup, Michael, Mattingsdal, Morten, Mattheisen, Manuel, Giddaluru, Sudheer, Nöthen, Markus M., Rietschel, Marcella, Cichon, Sven, Djurovic, Srdjan, Andreassen, Ole A., Jonassen, Inge, Steen, Vidar M., Puntervoll, Pål, Le Hellard, Stéphanie
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322240/
https://ncbi.nlm.nih.gov/pubmed/22444669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.02.025
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