Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data

We have tested published methods for capturing allelic heterogeneity and identifying loci of joint effects to uncover more of the “hidden heritability” of schizophrenia (SCZ). We used two tools, cojo-GCTA and multi-SNP, to analyze meta-statistics from the latest genome-wide association study (GWAS)...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Polushina, Tatiana, Giddaluru, Sudheer, Bettella, Francesco, Espeseth, Thomas, Lundervold, Astri J., Djurovic, Srdjan, Cichon, Sven, Hoffmann, Per, Nöthen, Markus M., Steen, Vidar M., Andreassen, Ole A., Le Hellard, Stéphanie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802566/
https://ncbi.nlm.nih.gov/pubmed/29249828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-017-0033-2
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