Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data

We have tested published methods for capturing allelic heterogeneity and identifying loci of joint effects to uncover more of the “hidden heritability” of schizophrenia (SCZ). We used two tools, cojo-GCTA and multi-SNP, to analyze meta-statistics from the latest genome-wide association study (GWAS)...

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Vydáno v:Transl Psychiatry
Hlavní autoři: Polushina, Tatiana, Giddaluru, Sudheer, Bettella, Francesco, Espeseth, Thomas, Lundervold, Astri J., Djurovic, Srdjan, Cichon, Sven, Hoffmann, Per, Nöthen, Markus M., Steen, Vidar M., Andreassen, Ole A., Le Hellard, Stéphanie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802566/
https://ncbi.nlm.nih.gov/pubmed/29249828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-017-0033-2
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