In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it

Binding of TNF to TNF receptor-1 can give a pro-survival signal through activation of p65/RelA NF-κB, but also signals cell death. To determine the roles of FLICE-inhibitory protein (FLIP) and caspase-8 in TNF-induced activation of NF-κB and apoptosis, we used mouse embryonic fibroblasts derived fro...

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Bibliographic Details
Main Authors: Moujalled, D M, Cook, W D, Lluis, J M, Khan, N R, Ahmed, A U, Callus, B A, Vaux, D L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321619/
https://ncbi.nlm.nih.gov/pubmed/22095280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.151
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