Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

Protein microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a determination of the critical surface concentration of TF required to trigger coagulation under flow. Whole blood supplemented with corn trypsin inhibitor (to inhibit factor XIIa) was perfused over microarray...

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Bibliographic Details
Main Authors: Okorie, Uzoma M., Denney, William S., Chatterjee, Manash S., Neeves, Keith B., Diamond, Scott L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321613/
https://ncbi.nlm.nih.gov/pubmed/18203955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-106229
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