Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells. Herein, we demonstrate that during the elimination of tran...

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Autors principals: Zirger, Jeffrey M, Puntel, Mariana, Bergeron, Josee, Wibowo, Mia, Moridzadeh, Rameen, Bondale, Niyati, Barcia, Carlos, Kroeger, Kurt M, Liu, Chunyan, Castro, Maria G, Lowenstein, Pedro R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321600/
https://ncbi.nlm.nih.gov/pubmed/22233583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.243
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