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Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells. Herein, we demonstrate that during the elimination of tran...

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Bibliografske podrobnosti
Main Authors: Zirger, Jeffrey M, Puntel, Mariana, Bergeron, Josee, Wibowo, Mia, Moridzadeh, Rameen, Bondale, Niyati, Barcia, Carlos, Kroeger, Kurt M, Liu, Chunyan, Castro, Maria G, Lowenstein, Pedro R
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321600/
https://ncbi.nlm.nih.gov/pubmed/22233583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.243
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