Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells

First-generation adenovirus can be engineered with powerful promoters to drive expression of therapeutic transgenes. Numerous clinical trials for glioblastoma multiforme using first generation adenoviral vectors have either been performed or are ongoing, including an ongoing, Phase III, multicenter...

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Detalhes bibliográficos
Main Authors: Barcia, Carlos, Gerdes, Christian, Xiong, Wei-Dong, Thomas, Clare E., Liu, Chunyan, Kroeger, Kurt M., Castro, Maria G., Lowenstein, Pedro R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2139984/
https://ncbi.nlm.nih.gov/pubmed/18084640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1740925X07000579
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