Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells

Lignende værker

• Immunology of neurological gene therapy: How T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses
  af: Lowenstein, Pedro R., et al.
  Udgivet: (2007)
• Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells
  af: Zirger, Jeffrey M, et al.
  Udgivet: (2012)
• T Cells' Immunological Synapses Induce Polarization of Brain Astrocytes In Vivo and In Vitro: A Novel Astrocyte Response Mechanism to Cellular Injury
  af: Barcia, Carlos, et al.
  Udgivet: (2008)
• Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions
  af: Lowenstein, Pedro R., et al.
  Udgivet: (2007)
• In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
  af: Barcia, Carlos, et al.
  Udgivet: (2006)