Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology

Soluble antigens diffuse out of the brain and can thus stimulate a systemic immune response, whereas particulate antigens (from infectious agents or tumor cells) remain within brain tissue, thus failing to stimulate a systemic immune response. Immune privilege describes how the immune system respond...

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Detalles Bibliográficos
Main Authors: Larocque, Daniel, Sanderson, Nicholas S. R., Bergeron, Josée, Curtin, James F., Girton, Joe, Wibowo, Mia, Bondale, Niyati, Kroeger, Kurt M., Yang, Jieping, Lacayo, Liliana M., Reyes, Kevin C., Farrokhi, Catherine, Pechnick, Robert N., Castro, Maria G., Lowenstein, Pedro R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922551/
https://ncbi.nlm.nih.gov/pubmed/20660723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913496107
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