TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in pri...

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Detalles Bibliográficos
Main Authors: Warnecke, Nicole, Poltorak, Mateusz, Kowtharapu, Bhavani S, Arndt, Boerge, Stone, James C, Schraven, Burkhart, Simeoni, Luca
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321150/
https://ncbi.nlm.nih.gov/pubmed/22344067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.17
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