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Antisense pro-drugs: 5'-ester oligodeoxynucleotides.
Oligonucleotides bearing a terminal lipophilic group attached through a biodegradable ester bond should be useful as antisense pro-drugs with improved cellular uptake. The synthesis of 5'-ester oligonucleotides is, however, problematic due to lability of the ester bond during aqueous ammonia tr...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1994
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC332106/ https://ncbi.nlm.nih.gov/pubmed/7816642 |
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