Antisense pro-drugs: 5'-ester oligodeoxynucleotides.
Oligonucleotides bearing a terminal lipophilic group attached through a biodegradable ester bond should be useful as antisense pro-drugs with improved cellular uptake. The synthesis of 5'-ester oligonucleotides is, however, problematic due to lability of the ester bond during aqueous ammonia treatme...
Tallennettuna:
| Julkaisussa: | Nucleic Acids Res |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
1994
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| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC332106/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7816642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.24.5492 |
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