Endotoxin Priming of Neutrophils Requires Endocytosis and NADPH Oxidase-dependent Endosomal Reactive Oxygen Species

NADPH oxidase 2 (Nox2)-generated reactive oxygen species (ROS) are critical for neutrophil (polymorphonuclear leukocyte (PMN)) microbicidal function. Nox2 also plays a role in intracellular signaling, but the site of oxidase assembly is unknown. It has been proposed to occur on secondary granules. W...

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Detalhes bibliográficos
Principais autores: Lamb, Fred S., Hook, Jessica S., Hilkin, Brieanna M., Huber, Jody N., Volk, A. Paige Davis, Moreland, Jessica G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320989/
https://ncbi.nlm.nih.gov/pubmed/22235113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306530
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