A common genetic variant in TLR1 enhances human neutrophil priming and impacts length of intensive care stay in pediatric sepsis

Polymorphonuclear leukocytes (PMN) achieve an intermediate or “primed” state of activation following stimulation with certain agonists. Primed PMN have enhanced responsiveness to subsequent stimuli, which can be beneficial in eliminating microbes but may cause host tissue damage in certain disease c...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Whitmore, Laura C., Hook, Jessica S., Philiph, Amanda R., Hilkin, Brieanna M., Bing, Xinyu, Ahn, Chul, Wong, Hector R., Ferguson, Polly J., Moreland, Jessica G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724530/
https://ncbi.nlm.nih.gov/pubmed/26729809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500856
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