Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is incurable and characterized by progressive paralysis of the muscles of the limbs, speech and swallowing, and respiration due to the progressive degeneration of voluntary motor neurons. Clinically indistinguishable ALS can be caused by genetic mutati...

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Hauptverfasser: Pokrishevsky, Edward, Grad, Leslie I., Yousefi, Masoud, Wang, Jing, Mackenzie, Ian R., Cashman, Neil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320864/
https://ncbi.nlm.nih.gov/pubmed/22493728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035050
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