TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion

Por Pokrishevsky, Edward, Grad, Leslie I., Cashman, Neil R.
Publicado no Sci Rep (2016)

Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans

Por Grad, Leslie I., Sayles, Leanne C., Lemire, Bernard D.
Publicado em 2005

Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding

Por Grad, Leslie I, Pokrishevsky, Edward, Silverman, Judith M, Cashman, Neil R
Publicado no Prion (2014)

Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)

Por Grad, Leslie I., Rouleau, Guy A., Ravits, John, Cashman, Neil R.
Publicado no Cold Spring Harb Perspect Med (2017)

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

Por Pokrishevsky, Edward, Grad, Leslie I., Yousefi, Masoud, Wang, Jing, Mackenzie, Ian R., Cashman, Neil R.
Publicado em 2012

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

Por Grad, Leslie I., Guest, Will C., Yanai, Anat, Pokrishevsky, Edward, O'Neill, Megan A., Gibbs, Ebrima, Semenchenko, Valentyna, Yousefi, Masoud, Wishart, David S., Plotkin, Steven S., Cashman, Neil R.
Publicado em 2011

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Por Grad, Leslie I., Yerbury, Justin J., Turner, Bradley J., Guest, William C., Pokrishevsky, Edward, O’Neill, Megan A., Yanai, Anat, Silverman, Judith M., Zeineddine, Rafaa, Corcoran, Lisa, Kumita, Janet R., Luheshi, Leila M., Yousefi, Masoud, Coleman, Bradley M., Hill, Andrew F., Plotkin, Steven S., Mackenzie, Ian R., Cashman, Neil R.
Publicado em 2014