Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron diseases: amyotrophic lateral sclerosis (ALS) a...

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Bibliografski detalji
Izdano u:Front Mol Neurosci
Glavni autori: Prasad, Archana, Bharathi, Vidhya, Sivalingam, Vishwanath, Girdhar, Amandeep, Patel, Basant K.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382748/
https://ncbi.nlm.nih.gov/pubmed/30837838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00025
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