Mechanism of Protein-Z-Mediated Inhibition of Coagulation Factor Xa by Z-Protein-Dependent Inhibitor: A Molecular Dynamic Approach

Protein Z is a plasma protein functioning as a carrier for ZPI. Protein Z also accelerates inhibitory effect of ZPI on factor Xa by 1000-fold. Inhibition of coagulation cascade via FXa by ZPI and other serpins is very important safety factor for normal homeostasis protecting human life against unwan...

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Bibliographic Details
Main Authors: Dayer, Mohammad Reza, Ghayour, Omid, Dayer, Mohammad Saaid
Format: Artigo
Language:Inglês
Published: International Scholarly Research Network 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320014/
https://ncbi.nlm.nih.gov/pubmed/22536522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/762728
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