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A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa)

Protein Z-dependent protease inhibitor (ZPI) and antithrombin III (AT3) are members of the serpin superfamily of protease inhibitors that inhibit factor Xa (FXa) and other proteases in the coagulation pathway. While experimental structural information is available for the interaction of AT3 with FXa...

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Autors principals: Chandrasekaran, Vasudevan, Lee, Chang Jun, Lin, Ping, Duke, Robert E., Pedersen, Lee G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723763/
https://ncbi.nlm.nih.gov/pubmed/19172319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-008-0444-3
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